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The Dutch Pharmacological Society, NVF

Cardiovascular and Renal diseases / Receptor Pharmacology and Signal transduction / Immunopharmacology, infections and inflammation / Neuropharmacology and brain disorders

The first objective of the Dutch Pharmacological Society is to facilitate Dutch research as well as the education in the use of drugs. The research covers the broad area from molecules, via cells, organs and organisms to populations. The Society wants to stimulate and facilitate national and international networks and collaborations in these areas. For that reason it develops activities that aim at exchanging knowledge and methodologies. Furthermore, it has the objective to promote the visibility of the discipline, both nationally and internationally.

During the Dutch Medicines Days we organize four sessions, most of them in collaboration with other FIGON partners.

In the session Immunopharmacology, infections and inflammation recent research in the field of immunological and infectious diseases and developments in preventive and treatment strategies will be highlighted. The main content will be based on a selection of abstracts submitted to the Figon Dutch Medicines Days 2017. The session aims to have a broad approach covering research data from both preclinical (in vitro and in vivo) as well as clinical research.

Dr. Linette Willemsen is assistant professor at the division of Pharmacology, dept. of Pharmaceutical Sciences, at the Utrecht University. Her research focuses on the mechanisms by which dietary components can modulate the mucosal and systemic immune response in preclinical in vitro and in vivomodels for food allergy and asthma. She is chairing this session on behalf of the Dutch Pharmacological Society (NVF), and is member of the organizing committee of the Figon Dutch Medicines Days.

For the session Neuropharmacology and brain disorders we will work together with The Brain Center Rudolf Magnus and program an invited speaker and make a selection from the list of abstracts submitted

The Brain Center Rudolf Magnus performs pre-clinical and clinical research in the field of neuroscience.

One of research missions is to discover and delineate mechanisms and processes which are fundamental to the development of neural systems and to the control of behavior. The goal is to unravel the pathogenesis and thereby provide newer treatment modalities for various neurological and psychiatric diseases. The institution also teaches basic neuroscience and pharmacology at bachelor and master levels.

This session will focus on the current developments in understanding the pathogenesis and the pharmacological treatment modalities for various neurological and psychiatric diseases.

Dr. Rahul Pandit is junior lecturer in pharmacology and pharmacotherapy and currently training to be a clinical pharmacologist. His predominant focus is pharmacology education for medical students. He is affiliated to the Department of Translational Neuroscience, UMC Utrecht.

Dr. Antoinette Maassen van den Brink is associate professor at the division of Pharmacology, dept. of Internal Medicine, at the Erasmus MC in Rotterdam. Her research focuses on the neurovascular aspects of migraine, with a special interest for the influence of female sex hormones on the pathophysiology of migraine. She is chairing this session on behalf of the Dutch Pharmacological Society, where she is a board member.

The session about Receptor Pharmacology and Signal Transduction is reserved on Tuesday. The NVF will organize this session in collaboration with the NVKFB and KNCV-section Farmacochemistry. For this morning event an invited lecturer is planned even as speakers for the abstracts submitted.

When and how a cell knows which signal is essential to adapt to changing environments? This question represents the basis of receptor pharmacology and signal transduction research. Our session includes research on understanding how a cell integrates sensing to signaling and transduces these signals from the plasma membrane to mitochondria, endoplasmic reticulum and to the nucleus. It consist of a complex series of intracellular cascades mediated by modulation of G-protein-coupled receptors, phospholipids, calcium, or protein phosphorylation. Understanding these processes might provide a detailed roadmap of how cells work, and ultimately of human physiology and pathologies. Therefore, this knowledge is essential for the development of novel therapeutic strategies to treat cancer, cardiovascular, neurological and metabolic disorders. These research questions fit well in the theme of the FIGON Drugs and Microbes, since it links the external signals to potential therapies against human diseases.

Prof. dr. Martine Smit is professor at the division of Medicinal Chemistry at the Vrije Universiteit Amsterdam. Her research focuses on unraveling and modulating (e.g. nanobodies) signaling networks activated by (oncogenic) G protein-coupled receptors, with a specific interest in (viral) chemokine receptors. She is chairing this session on behalf of the Dutch Pharmacological Society and section KNCV-Farmacochemie.

Dr. Amalia Dolga is an Assistant Professor and a Rosalind Franklin Fellow at the University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute of Pharmacy. Her lab investigates molecular mechanisms of neurodegeneration (Alzheimer's and Parkinson's disease), with a focus on potassium channel modulation, mitochondrial metabolism and inflammation. She is co-chairing this session on behalf of the Dutch Pharmaceutical Society."

Dr. ir. Ingrid Dijkgraaf is an associate professor at the Department of Biochemistry at Maastricht University. Her research focusses on development of molecular imaging agents to visualize cardiovascular diseases and cancer. She is co-chairing this session on behalf of the KNCV section Farmacochemie.

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